10 Best Prime Video Titles to Watch in September 2025

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Prime Video is packed this September, and honestly, it feels like they’re spoiling us. From pulse-racing action flicks to twisty dramas and a few unexpected gems, there’s no shortage of reasons to clear your weekend schedule. Whether you’re into high-stakes spy games, messy romances, or supernatural chaos, Prime’s lineup has something for everyone. Here’s a countdown of the 10 best new movies and shows streaming right now.

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10. Novocaine

In the mood for action with a twist? Novocaine has got you covered. Nathan Caine (Jack Quaid) is a quiet bank clerk caught in the middle of a bloody hostage scenario. His ace in the hole? A rare disease that renders him impervious to pain. What could have been a gimmick becomes a surprisingly warm, adrenaline-charged thrill ride, courtesy of Amber Midthunder’s added spark to the pandemonium.

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9. The Girlfriend

This creepy psychological thriller features Robin Wright as Laura, a thriving woman whose life is turned upside down by the arrival of her son’s new girlfriend, Cherry (Olivia Cooke). The tension between them unspools in a way that keeps you questioning all the time: who’s playing the other one, and who’s the pawn? It’s a six-part slow-burner that keeps you doubting every second.

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8. Gen V, Season 2

The Boys’ universe is just getting crazier. The second season of Gen V plunges Marie and her students into further madness at Godolkin University, where the boundaries between learning and militarization disintegrate rapidly. With a war on the horizon between humans and Supes, things have never been more intense. Look for insane gore, scathing satire, and numerous sinister turns.

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7. Hotel Costiera

Against the jaw-dropping cliffs of Positano, this fashion-forward thriller follows Daniel De Luca (Jesse Williams), a former Marine who now works as a hotel problem-solver. But he’s not merely smoothing over issues for wealthy visitors–he’s looking for the missing daughter of the owner of hotel. The sun-kissed location is stunning, but threats are around every corner, lending this series an upscale, international noir feel.

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6. Helluva Boss

After taking over YouTube, the popular animated show comes to Prime. Helluva Boss takes us along with Blitzo and his happy group of freelance assassins as they cause chaos throughout the underworld while coping with their complicated personal lives. If you enjoy your humor violent, raunchy, and slightly absurd, this one’s a quick binge. Bonus: the new special “Mission: Zero” is only available on Prime.

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5. Black Bag

Michael Fassbender and Cate Blanchett play married MI6 spies with a lethal secret: they might both be working against the agency. Half domestic drama, half paranoid spy thriller, the series is incisive, sophisticated, and full of suspicion. Worth watching alone is the dinner party sequence, a masterclass in psychological warfare.

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4. The Runarounds

This drama-fueled music tells the highs and lows of being young, ambitious, and slightly reckless. A group of young friends decides to start a rock band and go all out for an unforgettable summer pursuing their dreams. With original music, love triangles, and a lot of growing pains, it’s an authentic ride for anyone who ever dreamed of starting a band with their crew.

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3. Confidence Queen

This stylish Korean show is just right if you enjoy smart cons and elaborate scams. Park Min-young headlines the cast as one of three con artists who deploy their brainpower to bring down crooked elites. Stylish, witty, and relentlessly entertaining, Confidence Queen dishes up a new twist each week.

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2. Killer Heat

Joseph Gordon-Levitt stars in this Greek-se, sun-drenched noir as a private eye who investigates the suspicious murder of a shipping magnate’s heir. The further he digs, the more dark family secrets are revealed. With Shailene Woodley and Richard Madden joining in on the action, Killer Heat shoots Mediterranean glamour alongside old-school detective grime. 

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1. Play Dirty

Mark Wahlberg fronts an all-star ensemble in this dark heist thriller from Shane Black. When a crew of thieves hit the jackpot, betrayal and fireworks ensue. With LaKeith Stanfield, Rosa Salazar, and Keegan-Michael Key in tow, Play Dirty provides wall-to-wall tension and Black’s signature blend of grit and dark humor.

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Prime Video’s September slate is stacked with variety, whether you’re after laughs, suspense, or pure action. Grab the snacks, get comfy, and let the binge begin.

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